Thin films of heavily B-doped nanocrystalline diamond (B:NCD) have been investigated by a combination of high resolution annular dark field scanning transmission electron microscopy and spatially resolved electron energy-loss spectroscopy performed on a state-of-the-art aberration corrected instrument to determine the B concentration, distribution and the local B environment. Concentrations of 1 to 3 at.% of boron are found to be embedded within individual grains. Even though most NCD grains are surrounded by a thin amorphous shell, elemental mapping of the B and C signal shows no preferential embedding of B in these amorphous shells or in grain boundaries between the NCD grains, in contrast with earlier work on more macroscopic superconducting polycrystalline B-doped diamond films. Detailed inspection of the fine structure of the boron K-edge and comparison with density functional theory calculated fine structure energy-loss near-edge structure signatures confirms that the B atoms present in the diamond grains are substitutional atoms embedded tetrahedrally into the diamond lattice.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT05648110 Contacts Layout table for location contacts Contact: AstraZeneca Clinical Study Information Center 1-877-240-9479 information.center@astrazeneca.com Locations Layout table for location information United States, Missouri Research Site Not yet recruiting Kansas City, Missouri, United States, 64114 Argentina Research Site Not yet recruiting Buenos Aires, Argentina, C1039 Research Site Not yet recruiting Buenos Aires, Argentina, C1056ABJ Research Site Not yet recruiting Buenos Aires, Argentina, C1202ABB Research Site Not yet recruiting Mar del Plata, Argentina, 7600 Denmark Research Site Not yet recruiting Aarhus, Denmark, 8200 Research Site Not yet recruiting København Ø, Denmark, 2100 Research Site Not yet recruiting København, Denmark, 2300 France Research Site Not yet recruiting Dijon cedex, France, 21033 Research Site Not yet recruiting Paris, France, 75014 Research Site Not yet recruiting Paris, France, 75475 Korea, Republic of Research Site Not yet recruiting Gyeonggi-do, Korea, Republic of, 13620 Research Site Not yet recruiting Seoul, Korea, Republic of, 03080 Research Site Not yet recruiting Seoul, Korea, Republic of, 5505 Poland Research Site Not yet recruiting Krakow, Poland, 30-510 Research Site Not yet recruiting Lublin, Poland, 20-362 South Africa Research Site Not yet recruiting Newton, South Africa, 2113 Spain Research Site Not yet recruiting Majadahonda, Spain, 28222 Research Site Not yet recruiting Marbella (Málaga), Spain, 29603 Research Site Not yet recruiting Mérida, Spain, 06800 Research Site Not yet recruiting Pozuelo de Alarcón, Spain, 28223 Taiwan Research Site Not yet recruiting Taipei, Taiwan, TAIWAN Turkey Research Site Not yet recruiting Kocaeli, Turkey, 41380 United Kingdom Research Site Not yet recruiting London, United Kingdom, SE1 7EH Research Site Withdrawn London, United Kingdom, W1T 7HA Research Site Not yet recruiting London, United Kingdom, W1T 7HA Research Site Withdrawn Manchester, United Kingdom, M8 5RB Research Site Recruiting Manchester, United Kingdom, M8 5RB Research Site Not yet recruiting Nottingham, United Kingdom, NG5 1PB Research Site Not yet recruiting Oxford, United Kingdom, OX3 7LA Sponsors and Collaborators AstraZeneca More Information Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Publications: Al Jurdi A, Morena L, Cote M, Bethea E, Azzi J, Riella LV. 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SARS-CoV-2 BA.1 variant is neutralized by vaccine booster-elicited serum but evades most convalescent serum and therapeutic antibodies. Sci Transl Med. 2022 May 18;14(645):eabn8543. doi: 10.1126/scitranslmed.abn8543. Epub 2022 May 18. Maltezou HC, Anastassopoulou C, Hatziantoniou S, Poland GA, Tsakris A. Anaphylaxis rates associated with COVID-19 vaccines are comparable to those of other vaccines. Vaccine. 2022 Jan 21;40(2):183-186. doi: 10.1016/j.vaccine.2021.11.066. Epub 2021 Nov 27. NIH 2017 NIH. Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0. Available at: _applications/ctc.htm#ctc_50. Published 2017. Accessed 23 May 2022. Oganesyan V, Gao C, Shirinian L, Wu H, Dall'Acqua WF. Structural characterization of a human Fc fragment engineered for lack of effector functions. Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):700-4. doi: 10.1107/S0907444908007877. Epub 2008 May 14. 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Epub 2020 Jun 12. Erratum In: Lancet Infect Dis. 2020 Oct;20(10):e250. Layout table for additonal information Responsible Party: AstraZeneca ClinicalTrials.gov Identifier: NCT05648110 Other Study ID Numbers: D7000C00001 First Posted: December 13, 2022 Key Record Dates Last Update Posted: February 8, 2023 Last Verified: February 2023 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Yes Plan Description: Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal.
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